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Immune Reconstitution Inflammatory Syndrome in Natalizumab-Associated PML Neurol 77:1061-1067,1033, Tan, I.L.,et al, 2011 See this aricle in Pubmed Article Abstract Early immunologic rebound in natalizumab-associated PML has worse survival and neurologic outcome. PLEX/IA may accelerate IRIS and its impact on the final outcome is unclear. Cortico-steroid therapy provides a modest benefit and needs to be systematically studied in a controlled manner in the management of natalizumab-associated PML-IRIS.

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